血浆肾素、血管紧张素II、醛固酮含量在原发性高血压病患者治疗前后的临床意义

Clinical Value of Humeral RAA-system Activity Assessment in Patients With Essential Hypertension

目的探讨血浆肾素、血管紧张素Ⅱ、醛固酮水平在高血压病患者治疗前后的临床意义.方法选择原发性高血压病人122例,其中轻型20例,中型78例,重型24例,分别于治疗前后用放射免疫方法测定血浆PRA、AngⅡ、ALD含量.结果高压组血浆PRA、AngⅡ、ALD含量明显高于对照组(P＜0.01);轻、中、重型三组血浆PRA、AngⅡ、ALD含量呈逐步升高态势,组间相互比较有显著性和非常显著性意义(P＜0.05～0.01);治疗后血浆PRA、AngⅡ、ALD含量有较明显的降低,与治疗前比较有非常显著性意义(P＜0.01).结论降低原发性高血压患者血浆PRA、AngⅡ、ALD含量是治疗高血压病的关键;血浆PRA、AngⅡ、ALD是监测原发性高血压病疗效的可靠而且灵敏的指标.

Objective To investigate the clinical value of humeral RAA - system activity in patients with the essential hypertension before and after treatment. Methods Altogether 122 patients with essential hypertension were enrolled in this study, including 20 patients with mild, 78 patients with moderately severe and 24 patients with extremely severe hypertension. The plasma levels of renin activity （PRA）, angiotensin Ⅱ （AngⅡ ） and aldosterone（ALD） were assayed by radioimmunoassay （RIA） before and after appropriate treatment. Results The PRA, AngⅡ and ALD levels in the hypertensive patients were significantly higher than that of the controls（P〈 0.01）. The increments of PRA, AngⅡ and ALD levels were parallel with the severity of their blood pressure and showed significant differences between the groups （ P〈 0.05, 0.01 ）. While compared with the records before treatment, they were significantly decreased after proper treatment （P〈 0.01 ）. Conclusions The reductions of PRA, AngⅡ, and Aid are critical events in the treatment of hypertension, and they served as reliable and sensitive parameters representing the therapeutic efficacy.