摘要
目的探讨硒多糖对镉中毒大鼠肾的保护作用。方法经腹腔注射2.5 mg/kg.d氯化镉,连续3 d,诱发大鼠肾中毒,同时给大鼠饮用不同剂量的硒多糖水溶液30 d,分别测定肾组织匀浆的SOD、GSH-Px的活性,MDA含量,并同时观察大鼠肾组织的形态。结果硒多糖能明显提升SOD、GSH-Px的活性,显著降低MDA含量,使大鼠肾脏维持正常的生理功能及组织结构。结论硒多糖对镉中毒大鼠肾损伤有一定的保护作用。
Objective Study on the protective effects of selenium polysaccharides on cadmium induced renal damage of rat models. Methods The renal damage of rats were induced by intraperitoneal injection （i. p. ） with CdSO4 2.5 mg/kg, once per day for three days. The experimental groups were fed with selenium polysaccharides solution of different dose for 30 days. Renal tissue morphology and SOD, GSH- Px, MDA activities were examined thereafter. Results Selenium polysaccharides treatment resulted in obvious enhanced activities of SOD and GSH-Px and lowered MDA content, and made the rats＇ kidney maintained the normal function and tissue morphology. Conclusion Selenium polysaccharides has protective effects on cadmium induced renal damage of rat.
出处
《实用预防医学》
CAS
2005年第6期1311-1312,共2页
Practical Preventive Medicine
关键词
硒多糖
镉中毒
肾
保护作用
Selenium polysaccharides
Cadmium damage
Renal
Protective effects
