活脑康对缺血大鼠脑组织P38蛋白表达影响的实验研究

Influence of Huonaokang on Cerebral Protein P38 of Cerebral Ischemia in Rats

目的探讨缺血大鼠脑组织P38的变化及中药活脑康的保护作用。方法应用免疫组化方法,测定正常对照组(A组)、假手术组(B组)、模型组(C组)、活脑康治疗组(D组)、脑心通组(E组)P38的表达。结果与A组、B组比较,C组、D组、E组P38表达增多(P<0.001),与C组比较,D组、E组表达明显增多(P<0.001或P<0.05)。结论活脑康可上调突触素P38的表达,具有促进突触再建和增强、完善再建突触效能的作用。

Objective To explore the change of P38 in cerebral tissue of acute cerebral infarction in rats and the protection of Huonaokang. Methods The Cerebral ischemia rat models were established firstly. The expression of P38 was detected in normal contrd group （A）, sham operation group （B）, model group （C）, Huonaokang group （D） and Buchangnaoxintong positive control group （E） by immunohistochemical method. Results Contrary to group A and B,P38 in group C, D, E expressed increasingly（ P 〈 0. 001 ）. Conclusion Huonaokang could increase the expression of synaptophysin p38 and promote synapse reconstruction and enhance and consummate the function of reconstructive synapse.