晨尿微量白蛋白浓度检测对筛检早期糖尿病肾病的临床价值

Clinical Value of Urine Microalbumin for Screening Early Diabetic Nephropathy

目的探讨晨尿微量白蛋白浓度检测对筛选早期糖尿病肾病的临床价值。方法110例2型糖尿病病人纳入研究,收集晨尿及24h尿样,检测晨尿微量白蛋白浓度和24h尿白蛋白排泄率(UAER),并绘制晨尿白蛋白浓度受试者工作曲线(ROC)。结果晨尿微量白蛋白浓度与UAER相关(r=0.93,P<0.001)。晨尿微量白蛋白浓度的ROC100%敏感度截断点微量白蛋白浓度值为10mg/L(特异度为69%),敏感度与特异度最佳截断点微量白蛋白浓度值为25mg/L(敏感度90%,特异度88%)。结论晨尿微量白蛋白浓度检测对于筛选早期糖尿病肾病准确性较高。且较UAER简便、经济,可作为筛检2型糖尿病早期肾病的方法之一。

Objective To evaluate the clinical value of urine microalbumin for screening early diabetic nephropathy. Methods One hundred and ten patients with type 2 diabetes mellitus were enrolled. Urine in morning and that in 24 hours were collected to detect urinary albumin excretion rate （UAER） and draw the curve of urinary albumin concentration. Results Microalbumin in urine was related to UAER（ r = 0. 093, P 〈 0. 001 ）. The 100% sensitivity breakpoint was at 10 mg/L of microalbumin（specificity was 69% ）. The best breakpoint of sensitivity and specificity was 25 mg/L of microalbumin（sensitivity was 90 %, specificity was 88 % ）. Conclusion The concentration of micro,albumin in urine was accurate to screen early diabetic nephropathy. It was more convenient and sparing one than UAER.