胃肠道间质瘤的临床病理及免疫组化特征

Gastrointestional stromal tumors: clinicopathologic and immunohistochemial studies

目的探讨胃肠道间质瘤的临床病理、免疫组化特点,为其诊断提供依据。方法应用光镜观察26例胃肠道间质瘤的形态特征,用CD117、CD34抗体通过免疫组织化学S-P法对其进行标记检测。结果光镜下瘤细胞主要有梭形细胞及上皮样细胞两种形态,梭形细胞型20例,上皮样细胞型2例,混合细胞型4例。良性9例,恶性13例,交界性4例。免疫组织化学显示CD117阳性24例,CD34阳性22例,阳性率分别为95.5%及84.6%,且呈弥漫强阳性表达。结论胃肠道间质瘤主要有2种细胞形态和3种组合形式;确诊需要依靠CD117、CD34免疫组织化学标记。

Objective To explore the clinicopathologic and immunohistochemical features of gastrointestinal stromaltumors, identified its diagnosis and differential diagnosis. Methods 26 cases of GISTs were applied light microscope to observe its morphology and immtmohistochemical staining. Results A total of 26 cases of GISTs, 15 - 70 year old （ average 54.6 year old）, male： female = 1.16： 1. Microscopically, the tumors can exhibit spindle cells, epithelioid cells or a mixture of both our studies . The tumors were composed of spindle cells （20 cases） , epithelioid cells （2 cases） ,both cells （4 cases）, 9 cases were benign, 13 cases weremalignant, and 4 cases were borderline. Immunohistochemical staining. Showed 24 cases were CD117 positive, 22 cases were CD34 positive, and the positive rates were 95.5% and 84.6% respectively and showed diffuse strong expression. Conclusions GISTs are most common mesenchymals seen in the gastrointeseinal tract, there are 2 different morphology and 3 conbine forms. Immunohistochemical staining of CD117 and CD34 is necessary for its diagnosis.