7．5％氯化钠快速注入对出血性休克犬生化的影响

THE EFFECTS OF RAPID INFUSION OF 7.5% SODIUM C-HLORIDE ON THE BIOCHEMISTRY OF HEM- ORRHAGIC SHOCKED DOGS

目的:观察7.5％氯化钠(NaCl)快速注入对出血性休克犬生化的影响。方法:取5条杂种犬,失血至平均动脉压5．33- 6.70kPa且维持此血压1h后,2min内静脉注入7．5％NaCl(4ml／kg),观察4h。分别于失血前、给药前．给药后30min、 给药后3h检查血钾(K+)、钠(Na+)、氯(Cl-)及肌酐(Cr)。结果:失血后Cr高于失血前(P<0．05)。给药后30 min K+较给药前低(P<0.05);Na+及Cl-均较给药前升高(P<0．01)．Na+最高者达到了219mmol／L;Cr无明显变化。给 药后3 h K+比给药后30 min明显升高(P<0．05);Na+、Cl-及Cr均无明显变化,其中Cr呈上升趋势。结论:7．5％ NaCl快速注入对出血性休克犬的生化有明显影响。

Objective：To observe the effects of rapid infusion of 7.5% sodium chloride（NaCI） on the biochemistry of hemorrhagicshocked dogs Methods;Five mongrel dogs were bled to mean arterial pr-essure 5 33-6.70kPa and maintained for 1 hour.Each dog received 7.5% NaCl（4ml/kg）intravenously,the infusion time was 2 mins. Then observed 4 hoursPlasma Na＋,k＋,Cl-and Cr concentration was detected before hemorrhage, before drug inf-usion. 30 mins and 3 hrs after drug infusion. Results： The plasma Cr after hemorrhage was higher than t-hat before hemorrhage （P〈0.05） ,The plasma k＋ concentration at 30 rains after drug infusion was bower than that before drug infusion （P〈0.05）,The plasma Na＋.Cl- concentration at 30 mins after drug infusion was higher than that before drug inf-usion（P〈0.01）.the highest plasma Na＋ concentration was 219mmol/L but there was no change of Cr concentration. The plasma K＋ concentration at 3 hrs after drug infusion was higher than that 30 mins after drug infusion（P 〈0.05）, but no changes of Na＋. Cl-. Cr despite Cr appeared elevation. Conclusion：Rapid infusion of 7.5% NaCl do great effects on the biochemistry of hemorrhagic shocked dogs.