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皮质酮混合异丙酚对大鼠海马脑片CA1区长时程增强的影响 被引量：1

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摘要 异丙酚是目前临床常用的静脉全麻药物,但是一些应用异丙酚的患者在术后表现出遗忘等记忆功能障碍[1],这可能与异丙酚影响突触的可塑性有关[2].皮质酮是啮齿类动物重要的糖皮质激素,应激反应可以使动物体内皮质酮水平增高,可抑制大鼠海马脑片长时程增强(LTP)的形成[3].长时程抑制(LTD)和LTP是突触可塑性的重要形式,单独应用皮质酮或异丙酚可以易化大鼠海马脑片CA1区LTD的表达,皮质酮混合异丙酚则可以进一步增强LTD表达[4].应激与异丙酚双重因素对于LTP是否产生影响仍不清楚.本研究拟观察皮质酮混合异丙酚对大鼠海马脑片CA1区LTP的影响.
作者 尚游 姚尚龙 江山 曾因明
机构地区 华中科技大学同济医学院协和医院麻醉学教研室 徐州医学院江苏省麻醉学重点实验室
出处 《中华麻醉学杂志》 CAS CSCD 北大核心 2005年第10期783-784,共2页 Chinese Journal of Anesthesiology
基金 江苏省教育厅开放课题(KJS03084)
关键词 海马脑片CAl区 长时程增强 CA1区 异丙酚 皮质酮 大鼠 突触可塑性 记忆功能障碍 应激反应 糖皮质激素
分类号 R96 [医药卫生—药理学]
  • 相关文献

参考文献9

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二级参考文献13

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同被引文献12

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中华麻醉学杂志
2005年 第10期

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