国产紫杉醇抗卵巢癌和子宫内膜癌疗效观察

Curative Effect Observation of Native Paclitaxel for Ovarian Cancer and Endometrial Cancer

目的:考察国产紫杉醇对妇科肿瘤的疗效。方法:将2003年1月至2005年4月收治并确诊的卵巢癌和子宫内膜癌共21例作为观察对象,采用TP方案联合化疗,即紫杉醇注射液135 mg.(m2.d)-1,顺铂注射液d 1 40 mg、d 2 40 mg、d 3 20 mg静脉滴注,以上为1个疗程,每月一次。所有病例均治疗6个疗程。结果:16例卵巢癌和5例子宫内膜癌完成化疗后,所有的症状、体征完全消失。肿瘤无复发,观察时间超过4周,可以判断其近期疗效为完全缓解。结论:以国产紫杉醇为核心的联合化疗,对卵巢癌和子宫内膜癌有肯定的近期疗效,远期疗效尚需依照五年生存期判断。在联合化疗中,用药次序及预防变态反应措施必需严格,以保证安全。

Objective：To observe the curative effect for gynecological tumors. Methods：21 cases with ovarian cancer or endometrial cancer diagnosed and accepted by hospital between January 2003 and April 2005 are served as survey subjects who are treated with TP program, that is ,Paclitaxel injection135mg/m^2/day intervenous drop infusion within 3 hr. and Cisplatin intervenous drop infusion of 40mg for the first day and 40mg for the second day and 20mg for the third day. All above is served as one course of treatment. Once a month. All cases are trated for six courses. The curative effect is measured according to curative effect standad issued by WHO. Results：All symptoms and objective signs of 16 ovarian cancer and 5 endometrial cancer subjects are completely disappeared after the chemical treatment and no recurrence of tumor has exceeded over 4 weeks of observing time, the near curative effect of which can be judged as complete remission （CR）. Conclusion：The combination chemotherapy cored with native Paclitaxel has positive near curative effect for ovarian cancer or endometrial cancer,but the long term effect still needs to judge according to life pan of another five year. The medication order and allergic responseg prevention for the combination chemotherapy must be measured strictly to ensure the curative sectrity.