摘要
目的研究人体病理性瘢痕组织(增殖性瘢痕及瘢痕疙瘩)中转化生长因子β1(TGF-β1)及基质金属蛋白酶1(MMP-1)的表达。方法取10例病理性瘢痕切片,SP法检测TGF-β1及MMP-1,并与正常皮肤组织对照。结果免疫组化法沉淀病理性瘢痕中TGF-β1、MMP-1表达较正常皮肤组显著增高(P<0.05)。结论病理性瘢痕组织中TGF-β1及MMP-1均呈高表达,导致胶原沉积,瘢痕形成。
Objective To study the expressions of transforming growth factor-β1（TGF-β1） and matrix metalloproteinase-1 （MMP-1） in human hypertrophic scars and keloids. Methods The expres- sions of TGF-β1 and MMP-1 in 10 specimen of pathological scars were analyzed with SP method, which were compared with those in healthy skin. Results The expressions of TGF-β1 and MMP-1 were significantly higher in the pathological scars than those in healthy skin（P〈0. 05）. Conclusion The expressions of TGF-β1 and MMP-1 in hypertrophic scars and keloids were significantly increased, which is responsible for producing pathological scars.
出处
《江苏医药》
CAS
CSCD
北大核心
2005年第12期901-902,F0003,共3页
Jiangsu Medical Journal
