镉对中国林蛙外周血细胞微核及核异常的诱导效应

Inductive effects of cadmium chloride on micronuclei and nuclear anomalies in erythrocytes of Rana chensinensis

用不同剂量Cd2+注射林蛙,5 d后取血制片,光镜观察,探讨了不同剂量Cd2+对中国林蛙红细胞形成微核及核异常的影响.结果表明,Cd2+可诱导红细胞产生微核和核异常.Cd2+剂量高于0.2 mg/kg作用5 d后,对林蛙血细胞具有明显的毒性效应.Cd2+剂量低于0.5 mg/kg范围内,微核与核异常细胞率随Cd2+的增加呈上升趋势;当Cd2+剂量高于0.5 mg/kg时,微核与核异常细胞率随Cd2+的增加而下降.

In order to investigate the effects of Cd2^＋ on the micronuclei （MN） and other nuclear anomalies （ONA） in erythrocytes of peripheral blood of Rana chensinensis. Frogs are injected with different dosage Cd2^＋ for 5 d, making blood slides and observing with microscope, The results indicate that Cd2^＋ could induce the appearance of MN and ONA distinctly. When the dose oversteps 0.2 rng Cd2^＋/kg, Cd2^＋ could cause significant genetic damages to the peripheral blood cells of R. chensinensis,Within a dose range of 0.5mg Cd2^＋/kg, the frequencies of MN and ONA show a dosage-dependent increase. However, it decreases with the dose over 0.5 mg Cd2^＋/kg.