结直肠癌中β-连接素和突变型P_(53)基因表达与恶性生物学行为的关系

Study of the Ralationships Betwee the Expressions of P_(53) Gene and β-Catenin and the Manlignant Biologic Behaviors in Colorectalneoplasms

目的通过对P53及β-连接素在结直肠癌中表达情况的检测,研究其与该恶性肿瘤侵袭、转移的恶性生物学行为间的关系,为临床治疗及预后的预测提供可靠的依据。方法运用免疫组织化学的方法,对68例结直肠癌石蜡包埋组织标本进行P53及β-连接素两项指标的检测。结果结直肠癌中P53阳性表达在病理学分级、临床分期、肌层浸润深度、淋巴结转移情况中有差异,差异具有统计学意义,随分化程度降低,临床分期进展及肌层浸润深度增加及有淋巴结转移P53阳性强度增加,有显著性统计学意义。结直肠癌中β-连接素异常表达率在病理学分级、临床分期、淋巴结转移情况中有差异,差异具有统计学意义。P53阳性、β-连接素异常表达患者生存率低,差异有统计学意义。β-连接素异常表达与P53阳性表达及间有差异,且与阳性表达强度呈正相关,差异有统计学意义。P53及β-连接素是结直肠癌侵袭、转移的有用的辅助指标。结论P53及β-连接素是影响结直肠癌预后的重要因素,是对生存期具有预后价值的重要指标。

Objective To investigate the expressions of P53 gene and β-catenin and study the ralationships betwee invasion and metastasis of the manlignant biologic behaviors and them in colorectal neoplasms. Methods Immunohistochemistry method was used to detect the expression of P53 proteins and β-catenin in 67 cases of colorectal carcinoma. Results The stronger expression of P53 was positively related to the low clinicopathologica grade, clinical evolutional stage, invasive depth of muscular layer, lymphadenectomy, the differences were all evidently significant. Conclusion The abnormal expression of β-catenin is differential in clinicopathological grade, clinical, stage invasivedepth of muscular layer, lymphadenectomy and non-lymphadenectomy, the differences were all significant.