p53基因在口腔癌中的表达及其与临床、病理和预后间的关系

Expression of p53 Gene in Oral Squamous Cell Carcinoma and Its Relations with Clinical and Pathological Parameters and Prognosis of Patients

利用免疫组化技术对１１１例原发性人口腔粘膜鳞癌的ｐ５３蛋白表达进行了研究，并探讨了ｐ５３蛋白表达同口腔鳞癌的临床、病理和预后间的关系。研究结果表明：（１）口腔鳞癌有较高的ｐ５３蛋白阳性表达率（６９．４％），ｐ５３蛋白阳性表达可作为口腔癌癌变发生的一个标志。（２）ｐ５３蛋白表达情况同口腔癌的发生部位、性别、年龄、肿瘤大小、病理分级及淋巴结转移情况均无直接关系，同临床分期的关系也不十分明确。（３）ｐ５３蛋白染色阳性反应越强的口腔癌患者，其３年、５年生存率越差。（４）单因素ＣＯＸ风险比例模型分析证实ｐ５３蛋白阳性反应强弱并非影响口腔癌患者预后的主要因素，多因素ＣＯＸ模型分析未能建立有效的生存函数或危险率函数，说明所选指标及ｐ５３染色均不是影响口腔癌预后的非常有效的风险指标。

One hundred and eleven cases of oral squamous cell carcinoma(OSCC)were examined for overexpression of p53 protein by using immunohistochemical technique. Association of p53 protein overexpression with clinical and pathological parameters as well as prognosis of patients were also analyzed.p53 protein overexpression was cornmonly observed(69.4%)in the OSCC patients and might be used as a marker of carcinogenesis of OSCC.The level of p53 protein overexpression was correlated with the decreased three and/or five-vear survival rate of OSCC.The presense of p53 was not correlated with patient's sex and age,site and size of tumor,degree of differentiation,node status or clinical stage of OSCC,Single factor COX proportional hazards regression model analysis indicated that there was no significant relationship between p53 overexpression and prognosis of OSCC,MuItivariable COX model analysis failed to establish effective life function or risk rate function. This showed that all the parameters analyzed in this study as well as p53 overexpression were not significant or effective risk factors to predict prognosis of OSCC patients.