基层医院肺炎克雷伯菌的耐药现状调查

Drug Resistance Status of Klebsiella pneumoniae in Montane Hospital

目的调查基层医院肺炎克雷伯菌的耐药现状,为临床医师合理用药提供依据。方法用K-B法做体外药敏试验,用纸片确证试验检测产超广谱β-内酰胺酶(ESBLs)细菌。结果我院肺炎克雷伯菌产ESBLs率为24.8%;137株肺炎克雷伯菌对亚胺培南100%敏感,对阿米卡星和环丙沙星耐药率约为40%,对其余6种常用抗生素耐药率均>50%。结论基层医院也要重视细菌的耐药监测工作,预防医院感染的发生与流行。

OBJECTIVE To investigate drug resistance status of Klebsiella offer scientific basis for reasonable usage of antibiotics. METHODS Drug pneurnoniae in montane hospital and resistance was analyzed by using K-B method. The ESBLs producing strains detected by disc confirmed test. RESULTS The frequency of ESBLs- producing K. pneumoniae isolates were 24. 8% in our hospital. All of the 137 strains were susceptible to imipenem. And the resistant rate to ciprofloxacin was 40%, the resistant rate to other 6 antibiotics was all above 50%. CONCLUSIONS Supervising drug resistance of clinical isolates in montane hospital is also important for prevention of nosocomial infection breaking out and surveillance.