TPA诱导的血小板聚集的研究

A Study on TPA Induced Platelet Aggregation

应用不同浓度ＴＰＡ诱发血小板聚集，观察２０名正常人血小板的聚集率。结果显示：ＴＰＡ从５ｎｇ／ｍｌ到１０ｎｇ／ｍｌ之间，随着浓度的增加，血小板聚集率逐渐增加，最佳浓度为１０ｎｇ／ｍｌ。当ＴＰＡ浓度＞１０ｎｙ／ｍｌ时，继续增加ＴＰＡ浓度，血小板聚集率将不再升高，且于２０ｎｇ／ｍｌ时出现明显的解聚现象。对３６例急性白血病、１２例ＩＴＰ患者和３５例正常对照进行研究发现，ＴＰＡ诱导的血小板聚集率在两种疾病中均低于正常对照（Ｐ＜０．０１）。

sing different Concentrations(5ng/ml～30ng/ml)of TPA as a aggregating agent,we studed plateletaggregation (PAg)in 20 normal subjects.The result showed that,in lower concentration (10ng/ml),withthe increace of TPA concentration,the rates of PAg would go up.While the concentration of TPA was over10ng/ml,the rate of PAg would no longer ascend,and obvious disaggregation appeared when the concentra-tion was over 20ng/ml.Detecting the rates of PAg in 36 acute leukemia and 12 ITP patients with 10ng/mlTPA.we found that the rates of PAg in both group were,singificantly lovver than that in 35 normal controls(P<0.01),and it is higher in ITP group than in acute leukemia group (P<0.05).The results suggestedthat the further study of TPA induced PAg in blood diseases are necessary.