锰对男工性机能及其生殖结局的影响

Effectsofmanganeseonthesexualfuncitonandreproductiveoutcomeofmaleexposedworkers

为明确职业性接触锰是否损害男性生殖机能，采用生殖流行病学的方法，对３１４名锰作业男工和３１４名对照男工的性机能及其生殖结局进行了调查。结果发现，７４个作业点的２０９个空气ＭｎＯ２样品的几何平均浓度为０．１４５ｍｇ／ｍ３（０．００２～９．３４０ｍｇ／ｍ３），作业点和样品的超标率分别为４７．３％和４０．２％；锰作业男工生殖结局与对照组相比差异无显著性；其性机能障碍、阳萎和性欲减退发生率分别为８．９％、５．４％和１８．８％，均明显高于对照组（对照组上述异常发生率相应为４．８％、１．９％和１１．８％；ＲＲ＝１．９，２．８和１．６，９５％ＣＩ＝１．０～３．６，１．１～７．３和１．０～２．５，Ｐ＜０．０５），而且在不同工龄亚组间的分布差异亦有显著性（Ｐ＜０．０５或Ｐ＜０．０１），有随锰作业工龄增加而增高的趋势。提示：低浓度锰暴露对男性性机能障碍有病因学意义。

Todeterminewhetheroccupationalmanganeseexposuremaybedetrimentaltothemalereproductivefunctions,thesexualfunctionandreproductiveoutcomeof314maleexposedworkersand314malecontrolsubjectswerestudiedbythemethodofreproductiveepidemiology.TheresultsshowedthatthegeometricmeanofairMnO2levelwas0.145(0.002～9.340)mg/m3andtheexceedingrateswere47.3%from74worksitesand40.2%fromatotalnumberof209samples.Therewasnosignifi-cantdiferenceinthereproductiveoutcomebetweentheexposedandcontrolgroups.Theincidencesofthesex-ualdysfunction,impotenceandhyposexualityoftheexposedgroupwere8.9%,5.4%and18.8%respec-tively,significantlyhigherthanthoseofthecontrol(4.8%,1.9%and11.8%respective-ly;RR=1.9,2.8and1.6,95%CI=1.0～3.6,1.1～7.3and1.0～2.5,P<0.05).Theseincidencesweresignificantlyin-creasedastheworkstandingincreased.Itissuggestedthatthereisanetiologicsig-nificanceoflowlevelmanganeseexposureonthesexualdysfunction.