超氧化物歧化酶与膀胱癌分级分期关系的研究

Superoxide dismutase in patients with transitional carcinoma of bladder

为了解ＳＯＤ活性与膀胱癌生物学行为的关系，采用肾上腺素自体氧化法分析了２７例膀胱移行细胞癌病人肿瘤组织及非肿瘤粘膜，以及１０例非肿瘤病人膀胱粘膜的ＳＯＤ活性。结果显示：肿瘤组织ＳＯＤ活性低于正常组织，并与分级分期有关；复发及多发膀胱癌病人非瘤粘膜ＳＯＤ活性低于非肿瘤病人的膀胱粘膜（Ｐ＜０．０１）。ＳＯＤ活性的降低可能是膀胱癌的早期表现。

Superoxide dismutase (SOD) activity was evaluated in 27 cases of bladder carcinoma and in 10 spectimens of bladder mucosa free from tumor as controls. SOD activity, especially MnSOD,was markedly decreased,the poorer the tumor differentiation the lower the SOD level. Cancer with mucosa invasion had a lower SOD activity than superficial bladder cancer. A significant difference in SOD level in bladder mucosa was noted between bladder cancer patients and noncancer individuals. The decrease of SOD activity might be considered as a marker for the early detection of bladder cancer.