血和尿中人绒毛膜促性腺激素含量与膀胱肿瘤生物学行为的关系

Serum, urine β-HCG and the biological behaviour of bladder cancer

用放射免疫方法（ＲＩＡ）检测２１例膀胱肿瘤患者（试验组）和同例数泌尿科非肿瘤患者（对照组）血和尿中人绒毛膜促性腺激素（β－ＨＣＧ）含量。试验组血样本β－ＨＣＧ均值为１８．２３ＩＵ／Ｌ，对照组为６．６０ＩＵ／Ｌ，Ｐ＜０．０２５，试验组尿β－ＨＣＧ均值为４９．９ＩＵ／Ｌ，对照组为７．３４ＩＵ／Ｌ，Ｐ＜０．０２５。结果表明：试验组血和尿中β－ＨＣＧ含量均显著高于对照组。并将试验组β－ＨＣＧ含量情况与肿瘤细胞病理分级作相关分析，血样本相关系数ｒ＝０．９３２７，尿样本ｒ＝０．８９８２。结果提示：试验组血和尿β－ＨＣＧ含量与肿瘤细胞的分级有密切关系，含量越高，细胞分化越低，肿瘤预后越差。

β-HCG in serum and urine were detected by RIA for 2l cases of transitional cell carcinoma of bladder and in 21 non-cancer individuals as controls β-HCG in cancer patients(serum l8.23IU/L, urine 49. 90 IU/L)were much higher than the controls(serum 6.60IU/L,urine 7.34IU/L)(P< 0. 05). The correlation coefficients between β-HCG levels and cancer cell grade were r=0. 9327 for serum and r=0.89l9 for urine suggesting that the higher the β-HCG level the poorer the cancer cell differentiation,thus the poorer the prognosis.