营养素的摄入水平与前列腺癌关系的病例对照研究

Nutrient intake and prostate cancer risk:a case control study

１９９１年在全国１２个城市实施了以医院为基础的多中心协作研究，采用ｌ：４匹配的病例对照研究方法，目的在于揭示营养素的摄入水平与前列腺癌的关系。调查了前列腺癌现患病例１５４例，医院非前列腺癌癌对照１５４例，医院非癌病人对照１５４例，随机邻居对照３０８例。结果显示下列营养素与前列腺癌发病存在相关关系：总脂肪的比值比（Ｏｄｄｓｒａｔｉｏ，ＯＲ）＝１．２８，９５％可信限（ｃｏｎｆｉｄｅｎｃｅｉｎｔｅｒｖａ１，Ｃｌ）为１．０７～１．５４（Ｐ＜０．０１）；饱和脂肪ＯＲ＝１．３４，９５９６，ＣＩ为１．１２～１．６２（Ｐ＜０．０１）；动物脂肪ＯＲ＝１．４８，９５％ＣＩ为１．２３～１．７９（Ｐ＜０．００１）；膳食纤维ＯＲ＝０．８０，９５％ＣＩ为０．６６～０．９５（Ｐ＜０．０５）；胡萝卜素ＯＲ＝０．８４，９５％ＣＩ为０．７１～０．９９（Ｐ＜０．０５）；维生素ＣＯＲ＝０．８０，９５％ＣＩ为０．６８～０．９７（Ｐ＜０．０５）；硒ＯＲ＝１．３０，９５％ＣＩ为１．０７～１．５６（Ｐ＜０．０１）。趋势检验结果显示，前列腺癌与总脂肪、胡萝卜素、硒、饱和脂肪酸、动物脂肪的摄入水平存在着一定的剂量反应关系。总能量、总蛋白质、碳水化合物、视黄醇?

To evaluate nutrient intake and prostate cancer risk, a hospital based case-control study was conducted in l2 cities in China. All the prostate cancer cases were diagnosed during l989～199l and have been confirmed on histopathologic studies. Interview was made with l54 prostate cancer patients,154 hospitalized noncancer patients and 308 neighborhood controls. The following nutrient intakes were found to be related to the incidence of prostate cancer:Odds ratio(OR)=1.28, 95% confidense interval(CI)=1.07～1.54,(P<0.0l) for total fat;OR=1.34, 95%CI=1.12～1.62(P<0.0l)for saturated fatty acid;OR=1.48, 95% CI=1.23 ～1.79(P<0.001)for animal fat. Carotene(OR=0.84. 9596 CI = 0.70～0.99),Vit C(OR=0.80, 95%CI =0.68～0.97)and dietary fiber(OR=0.80, 95% CI=0.66～0.95)showed negative association. OR for prostate cancer with selenium was l.30 with a 95 % CI of l.07～1.56.The trend tests showed that there might be a dose-response between prostate cancer and total fat,saturated fatty acid, animal fat,Vit C and selenium intake,On the other hand,total energy intake and the dietary intake of total protein, retinol,thiamine,tocopherol and such minerals as zinc, iron, copper and magnesium were not linked with prostate cancer.