性行为、癌前疾病与前列腺癌关系的病例对照研究

Sexual behavior, non-cancereous diseases and prostatic cancer: a case-control study

为探讨前列腺癌的危险因素，１９９１年在中国１２个城市实施了以医院为基础的病例对照研究。以１３８例经组织学确认的前列腺癌现患病例为病例，６３６例为对照（其中１５６例医院癌对照，１５８例医院非癌对照和３２２例邻居对照），病例与对照以年龄相差不超过５岁和本地居住超过１０年为匹配条件。研究结果显示：首次遗精年龄具有超额危险，ＯＲ１＝１．９３．ＯＲ２＝１．９３，ＯＲ３＝４．２，Ｐ＜０．０５。首次遗精年龄越早，危险性越大，呈明显剂量反应关系。手淫习惯，病例与三种类型对照比较有明显超额危险，ＯＲ１＝１．８．ＯＲ２＝１．９，ＯＲ３＝２．３．Ｐ＜０．０５。婚烟状态，再婚者危险性最高，离异及鳏夫其次，连续婚烟最低。生育孩子数越多越危险，呈现剂量反应关系。前列腺炎及前列腺增生病例与三种类型对照比较，有明确的统计学关联。前列腺炎ＯＲ１＝４．０，ＯＲ２＝６．６，ＯＲ３＝４．９，Ｐ值均＜０．０５。前列腺增生ＯＲ１＝６．１，ＯＲ２＝６．６．ＯＲ３＝４．３．Ｐ＜０．０５。

A hospital-based case-control study was conducted in 12 cities in China to evaluate the correlation of marital status, sexual behavior, prostatitis and BPH to prostatic cancer. A total of 138 cases of histologically confirmed prostatic cancer diagnosed between 1989 and 1992 and 636 controls (156 hospitalized cases of other cancer,158 hospitalized non-cancer cases and 322 neighborhood controls) of comparable age were interviewed and included in the study. The remarried, those with the first nocturnal emission at an earlier age(<14), those interesting in opposite sex at a younger age(<15), young adults(<30)with frequent sexual intercourse, elderly(>70)losing interest in sexual activity and those with habit of masturbation were more likely to have prostatic cancer as compared to the controls. A history of prostatitis and of BPH was associated with a significantly increased risk of prostatic cancer. The results suggested that men with a stronger sexual drive and a history of prostatitis or BPH might have an increased risk of prostatic cancer.