肝豆状核变性病患者头发微量元素的含量分析

Analysis and Discussion on Trace Elements in Hair of Patients with Hepatolenticular Degeneration

为了解肝豆状核变性患者头发微量元素的含量,以及微量元素与肝豆状核变性病的关系,用火焰原子吸收分光光度计分别测定了患者和健康者头发的铜、锌、钙、铁的含量。结果表明,患病组头发与健康头发铜、锌、铁含量均在正常范围,无显著性差异(P>0.05),而患者头发钙含量明显低于健康组头发含量,有显著性差异(P<0.05)。可见患者发铜、锌、铁含量测定对肝豆状核变性病临床诊断没有意义,而发钙与肝豆状核变性病有密切关系,能反映患者体内钙代谢情况,提示患者排铜治疗的同时应及时补钙。

To know about the content of trace elements in hair of patients with hepatolenticular degeneration disease and reveal their relation, the content of Cu, Zn, Ca, Fe in hair of patients with hepatolenticular degeneration disease was determined by flame atomic absorption spectrophoto meter. The results show that the content of Cu, Zn, Fe are all in the normal scale （ P 〉 0.05）, the content of Ca is obviously lower than the normal value （P 〈 0.05）. It concludes there is no revelant important to clinic diagnoses by measuring the content of Cu, Zn and Fe in patient＇s hair. The measure of Ca content from hair, which has great significance with hepatolenticular degeneration disease, can manifest the patient＇s metabolic activity of Ca, enables the treatment to go dually with eduction of Cu and supplement of Ca.