北美地区鹿的慢性消耗性疾病

Deer Chronic Wasting Disease in North America Region

鹿慢性消耗性疾病(CWD)是鹿类动物的传染性海绵状脑病(TSE)。它是由朊病毒(PrP)引起的,临床主要表现为慢性型消耗,体重逐渐下降,行为异常,最后致死。该病主要感染北美地区的黑尾鹿、白尾鹿和美洲马鹿,一些野生和家养的反刍动物如牛、绵羊和山羊与染病鹿直接或间接接触也可被感染。目前还不能确定CWD与人和其它动物的TSE类疾病的关系。它的起源、发病机理、传播机制和途径尚不清楚。尽管还没有证据证明CWD可传染给人类,但是它对人类有潜在威胁。

Chronic wasting disease is one type of transmissible spongiform encephalopathy of deer and elk. Its etiological agent is prion protein, and its clinical symptoms are mainly characterized by chronic wasting, loss of body condition , behavioral changes and leading to death. This disease can infect specific species of native North American deer, including mule deer and white - tailed deer as well as Rocky Mountain elk. Some wild ranging and captive ruminants, such as cattle, sheep and goat, can be infected by direct or indirect contact with CWD- infected deer and elk. It is still not known the relationship between CWD and any other TSE of animals or people. It has been not known the disease origins, pathogenesis, transmission mechanisms and mode. Although there is no evidence that CWD has been transmitted to human, it may have the potential to infect human.