慢性阻塞性肺疾病血浆丙二醛和谷胱甘肽过氧化物酶的研究

Changes of plasma malonyl dialdehyde and glutathione peroxidase in patients with chronic obstructive pulmonary disease during exacerbation

目的研究慢性阻塞性肺疾病(COPD)患者急性发作期血浆丙二醛(MDA)和谷胱甘肽过氧化物酶(GSH-PX)含量的变化,探讨其临床意义。方法用DNTB法对22例阻塞性肺疾病患者(COPD组)和29例健康人(对照组)血浆GSH-PX活性进行测定,用TBA法测定其MDA的含量。结果血浆GSH-PX含量COPD组小于对照组,两者比较差异有显著性(P<0.05);MDA的含量COPD组较对照组增高,差异也有显著性(P<0.01)。结论慢性阻塞性肺病患者急性发作期存在氧化与抗氧化平衡的失调,在疾病的发生、发展过程中起重要作用。

[Objective] To study the changes of plasma malonyl dialdehyde（MDA） and glutathione peroxidase （GSH-PX） in patients with chronic obstructive pulmonary disease（COPD） during exacerbation, ahd to discuss their clinical significance. [Methods] The levels of plasma MDA and GSH-PX in 22 eases of COPD（COPD group） and 29 eases of healthy persons（control group） were examined by methods DNTP and TBA, correspondingly. [Results] The levels of GSH-PX in COPD group were lower than those in control group, the differences were significant （P 〈 0.05）; The levels of MDA in COPD group were higher than those in control group, the differences were significant, too （P 〈0.01）. [Conelusion] There is an oxidant-antioxidant imbalance during exacerbation of chronic obstructive pulmonary disease, those may play an important role in the pathogenesis of COPD.