不稳定心绞痛患者血清超敏C反应蛋白检出的意义

High sensitivity C-reactive protein assays in serum of patients with unstable angina

[目的]评估不稳定型心绞痛(UA)患者血清超敏C反应蛋白(hs-CRP)变化的临床应用意义。[方法]测定105例UA患者(UA组)发病和稳定状态时及90例正常对照者(C组)的血清hs-CRP水平,观察同一患者治疗前后患者hs-CRP的变化;并分析随访6个月期间,治疗后的hs-CRP下降与患者心脏事件发生率的差异。[结果]UA组患者发病时和稳定时的hs-CRP值分别为(7.89±2.29)mg/L及(7.04±2.03)mg/L,均显著高于C组的(1.37±1.05)mg/L(P<0.01);稳定时hs-CRP下降幅度明显(≥0.5mg/L)69例和下降不明显36例,6个月内心脏事件发生率分别为16.8%和37.3%,两者差异显著(P<0.05)。[结论]UA患者血清hs-CRP水平增高,治疗后hs-CRP水平无明显下降患者6个月内发生心脏事件的危险性较高。

[Objective] To assess the value of the serum high sensitive C- reactive protein （hs- CRP） to predicate prognosis in patients with unstable angina （UA）. [ Methods] The serum hs - CRP levels in 105 patients with UA on both of active and stable stages and 90 health persons for control were measured. All cardiovascular events （angina pectoris, myocardial infarction, death） were carefully observed and recorded in following 6 months after discharge. [Results] Both hs- CRP levels of patients with UA on active and stable stages being （7.89± 2.29） mg/ L and （7.04 ± 2.03） mg/L respectively, both were higher than that of the controls （1.37 ± 1.05） mg/L （P 〈 0.01）. The frequency of cardiovascular events of patients with UA whose hs - CRP levels in 6 months following up decreasing and not on the stable stages were 37.3 % and 16.8 % respectively （P 〈 0.05）. [Conclusions] The hs- CRP levels of patients with UA are significantly higher than that of health persons. Patients whose hs - CRP levels did not decreasing during discharge would be easier to have cardiovascular events.