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脑源性神经营养因子与缺血性脑损伤 被引量:3

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摘要 脑源性神经营养因子(Brain-derivedneurotrophicfactor,BDNF)属神经营养因子家族成员,具有维持神经元存活的作用,对缺血性脑损伤有保护作用。本文综述了BDNF的基因定位、组成、分布及其相关受体;BDNF对缺血性脑损伤的保护作用;其保护机制可能包括抑制兴奋性氨基酸的毒性和稳定神经元内Ca2+浓度、调节自由基代谢、抑制Caspase-3活性、调节Bax和Bcl-2的表达等。
出处 《中国医学文摘(老年医学)》 2005年第4期239-242,共4页
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