置速率控制膜型控释消炎痛和止血芳酸IUD者经血外周血中ACP　AKP含量变化

THE CHANGES OF ACID PHOSPHATASE、ALKALLINE PHOSPHATASE IN THE MENSTRUAL AND PERIPHERAL BLOOD OF INSERTED IUD WITH RATE-LIMITING MEMBRANE CONTROLLING DELIVERY OF INDOMETHACIN AND P-AMINORMETHYL BENZOIC ACID

对置速率控制膜型控释消炎痛（ＩＭ）和止血芳酸（ＡＭＣＭ）宫内节育器（ＩＵＤ）妇女月经血和外周血中酸性磷酸酶（ＡＣＰ）、碱性磷酸酶（ＡＫＤ）含量进行分析测定，同时对月经血量进行观察。结果表明，置器后１、３、６周期月经血量分别比置器前下降２３．８０％、３０．６６％、２６．２３％。置器后１、３、６周期月经血中和置器后第６周期的外周血中ＡＣＰ含量与置器前比较差异无显著意义（Ｐ＞０．０５）。ＡＫＰ含量外周血中置器前后差异无显著意义（Ｐ＞０．０５），而经血中含量置器后１、３、６周期分别与置器前比较均显著降低（Ｐ＜０．０１）。提示ＩＭ─ＡＭＣＭＩＵＤ能够减少月经血量，且避孕效果高，副作用少，是一种新型速率控制膜型控释药物的ＩＵＤ。

This paper reports the change of acid phasphatase、alkalline phosphatase in the menstrual and perpheral blood of women in pre─and post─insertion of intrauterine contraceptive devices(IUD) with rate─limiting menbrane controlling delivery of indomethacin(IM)and P─aminormethyl benzoic acid(AMCM).At the same time,the quantity of menstrual blood were also observed. It were found that the quantity of menstrual blood becreace 23.80%、30. 66%、26. 23% respectively at first、three and six cycler post─msertion in comparison with pre─insertion of IM─AMCM IUD. The changs of acid phosphatase,alkalline phosphatase, as compared pre─and post─insertion were no statitcal difference(P>0.05)in the menstrual blood at the six cycle. The results indicate that this device reduces quantity of menstrual. SO the IM─AMCM IUD is a new type active IUD of rate limiting membrane controlling delivery drug and hight effeetivecontraceptions with few side effects.