多代饮奶对小鼠骨钙代谢的影响

Effect of Multi-generation Drinking Milk on the Mouse Bone Calcium Metabolizing Factors

目的:研究多代饮用牛奶对小鼠血钙、血清碱性磷酸酶(ALP)、骨钙素(BGP)等骨钙代谢指标的影响,以探讨多代饮奶对骨钙代谢的影响规律。方法:取四周龄BALB/c小鼠60只,饲养于动物房,白天、黑夜各12h,按体重随机分为两组,一组为饮奶组,按体重500g/60Kg10=0.083g/g灌奶;另一组为不饮奶组,按体重0.083g/g灌胃去离子水。每代在其子代出生一个月后取样测定各项指标。结果:实验组血清碱性磷酸酶(ALP)、骨钙素(BGP)明显高于对照组(P<0.05);实验组第三代与第一代之间有统计学意义(P<0.05);对照组代与代之间没有统计学意义(P>0.05);血清钙含量对照组和实验组没有统计学意义(P>0.05)。结论:多代饮奶可促进小鼠骨钙吸收,进而促进骨骼发育和骨健康。

Objective ： To study the effect of multi - generation drinking milk on the bone metabolizing factors such as serum calcium, ALP, BGP, etc. Methods ： Sixty BALB/c mice of 4-week years old were chosen and divided into two groups randomly by weight, one is the drinking milk group, infused with 0.083g/g of milk, another group infused with the same quantity of distilled water. The items were determined within one month after the birth of their filial generation. Results： ALP, BGP of the drinking milk group were higher than that of another group significantly （ P 〈 0.05）. Within the drinking milk group, ALP, BGP of the third generation were significant different with that of the first generation（ P 〈 0.05） ; but there is no significant difference among the generations of the contrast group （ P 〉 0.05）. The blood calcium, has no significant difference between the two groups （ P 〉 0.05）. Conclusion ： Multi-generation drinking milk could promote the absorption of bone calcium, at last promote the growth and health of bone.