Issues within Keratinocyte Growth Factor （KGF） research

As the seventh member of Fibroblast Growth Factor （FGF） family, Keratinocyte Growth Factor （KGF or FGF-7） is observed tp mediate epithelial cell proliferation and differentiation in a variety of tissues. In this article, such following issues within KGF research were reviewed, as （1） KGF functioning pathways： experimental results demonstrated the paracrine pathway of KGF played main role in mesen- chymal-epithelial interactions whereas KGF itself was under the control of a feedback regulation, autocrine provided KGF alternative functioning way particularly in tumourogenesis; （2） KGF in apoptosis： a few of investigations recently illustrated KGF mediated cell survival was based on its mitogenic function via stimulating cell growth, moreover KGF could inhibit the ROS-induced apoptosis through Nrf-2 pathway; （3） KGF during tumourogenesis： high expression of KGF enhanced progression, motility and invasiveness of tumor cells and various cancers, in company with paracrine loop replaced by autocrine loop, meanwhile KGF clearly played the early signal in the progression of breast cancer; （4） Medical application and administration of KGF： KGF had been successfully used in several preclinical models of radiation and chemotherapy-induced mucositis, and developed into commercial medicine （i.e. Palifermin ）, however more effective delivery systems are still under trial.

作为成纤维细胞生长因素(FGF ) 家庭的第七个成员， KeratinocyteGrowth 因素(KGF 或 FGF-7 ) 被观察调停在许多纸巾的上皮的细胞增殖和区别。在这篇文章，在 KGF 研究以内的如此的后面的问题被考察，作为(1 ) KGF 工作小径：试验性的结果证明而 KGF 本身在一条反馈规定的控制下面， KGF 的 paracrinepathway 在 mesen-chymal-epithelial 相互作用起了主要作用， autocrine 提供了 KGF 特别地在 tumourogenesis 的其他的工作方法；(2 ) 在 apoptosis 的 KGF：调查的一些最近， illustratedKGF 调停了细胞幸存经由刺激细胞生长基于它的 mitogenic 功能， moreoverKGF 能通过 Nrf-2 禁止导致 ROS 的 apoptosis 小径；(3 ) KGF 在 KGF 的 tumourogenesis:high 表示期间提高了前进，活动性和肿瘤房间和各种各样的癌症的侵略海角，在有 autocrine 循环代替的 paracrine 循环的同伴，同时， KGF 清楚地在乳癌的前进玩了早信号；(4 ) 医药申请和管理 ofKGF：KGF 是成功地在放射的几个现出症状之前的潜的模型使用导致 andchemotherapy 的 mucositis，并且发展成商业药(即 Palifermin ) ，然而，更有效的交货系统仍然在试用下面。