摘要
Two metabolites(A and B) were isolated from a mangrove endophytic fungus Stysanus like sp.(#2492) from the South China Sea.Their structures were elucidated by spectral data as N-(2’-hydroxytetracosyl)-2-amino1,3,4-trihydroxyoctadecane(A) and γ-stearolactone(B).In the primary bioassay,compound B did not exhibit significant inhibitory activity to DNA topoisomerase hTOP Ⅰ,and also had no significant inhibitory activity to tumor cell lines Bel-7402 and NCIH-460.It was the first report that γ-stearolactone(B) isolated from marine fungus as natural product.
Two metabolites（ A and B） were isolated from a mangrove endophytic fungus Stysanus like sp. （#2492） from the South China Sea. Their structures were elucidated by spectral data as N - （2＇ - hydroxytetracosyl） -2 - amino - 1,3,4 - trihydroxyoctadecane （A） and γ-stearolactone （B）. In the primary bioassay, compound B did not exhibit significant inhibitory activity to DNA topoisomerase hTOP Ⅰ , and also had no significant inhibitory activity to tumor cell lines Bel - 7402 and NCIH - 460. It was the first report that γ - stearolactone （B） isolated from marine fungus as natural product.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2005年第6期790-792,共3页
Chemical Research and Application
基金
国家863计划资助项目(2001AA624010)
广东自然科学基金资助项目(04300674)
广东省科技计划资助项目(2004B30101017)
