沙眼衣原体、支原体属感染及药物敏感度分析

Infection and antimicrobial susceptibility of Chlamydia trachoma and mycoplasma

目的了解女性非淋菌性宫颈炎患者沙眼衣原体(CT)、支原体感染及药敏情况。方法采集342例女性非淋菌性宫颈炎患者的宫颈分泌物进行CT抗原检测、支原体培养及药敏试验。结果CT和支原体感染共249例(72.8%),其中解脲脲原体(Uu)129例(37.7%),显著高于人型支原体(Mh)15例(4.4%)。Uu+Mh混合感染60例(17.5%)及Uu+Mh+CT混合感染45例(13.2%)(P<0.005)。246株支原体对环丙沙星、红霉素、氧氟沙星、克拉霉素、阿奇霉素、四环素、原始霉素、交沙霉素和多西环素的耐药率分别为76.5%、45.9%、43.5%、35.3%、29.4%、10.6%、3.5%、2.4%和2.4%。结论CT和支原体是引起非淋菌性宫颈炎主要病原体,支原体的耐药性监测对指导临床治疗具有重要意义。

Objective To investigate the clinical feature and antimicrobial susceptibility of Chlamyolia trachoma （CT）, mycoplasma in female patients with non-gonococcal cervicitis. Methods A total of 342 cervical secretion samples from female patients with non-gonococcal cervicitis were collected. C. trachoma antigen was detected by immunoassay and mycoplasma was cultured. Antimicrobial susceptibility test was also performed. Results C. trachoma and mycoplasma infections were confirmed in 249 patients （72.8%）. Among them, Ureaplasma urealyticum （Uu）, Mycoplasma h ominis （Mh）, Uu＋Mh mixed infection and Uu＋Mh＋CT mixed infection were identified in 129 （37.2%）, 15 （4.4%）, 60 （17.5 % ）, and 45 （13.2%） of the patients respectively. Uu infection was significantly more than other infections （P〈0. 005）. The resistance of 246 mycoplasma isolates was as follows （resistance rate）： ciprofloxacin （76.5~）, erythromycin （45.9%）, ofloxacin （43. 5%）, clarithromycin （35. 3%）, azithromycin （29.4%）, tetracycline （10.6%）, pristinamycin （3.5%）, josamycin （2.4%）, and doxycycline （2.4%）. Conclusions C. trachoma and mycoplasma are main pathogens of female non-gonococcal cervicitis. The surveillance of resistance in mycoplasma is important for effective treatment.