飞行员血管紧张素转换酶、血管紧张素原和血管紧张素受体1基因多态性分析

A study of gene polymorphism of the angiotensin-converting enzyme,angiotensinogen and angiotensin receptor type 1 in pilots

目的:了解飞行员血管紧张素转换酶(ACE)基因插入/缺失(I/D)多态性、血管紧张素原(AGT)基因M235T多态性和血管紧张素受体1(ATR1)基因A1166C多态性情况,探讨三种基因多态性与飞行员耐力可能的关系。方法:用聚合酶链反应(PCR)扩增和产物酶切技术检测253例飞行员和236例健康对照者的三种基因多态性。结果:飞行员组ACE II基因型(45.06%)和I等位基因频率(0.67)显著高于健康对照组(分别为31.36%和0.52),而AGT和ATR1基因多态性在两组间无明显差异。结论:ACE I基因有可能在飞行员的飞行耐力中起重要作用。

Objective：To understand gene polymorphism of the angiotensin-converting enzyme,angiotensinogen and angiotensin receptor type 1 in pilots, and to investigate the association between gene polymorphism and the perfomance of the pilots. Methods： 253 pilots and 236 healthy control subjects were genotyped for the insertion/delation （I/D） polymorphism of the angiotensin- converting enzyme （ACE） gene, M235T polymorphism of angiotensinogen （AGT） gene and A1166C polymorphism of angiotensin receptor type 1 （ATR1） gene by the polymerase chain reaction （PCR）. Results： It was showed the genotype Ⅱ and Ⅰ allele frequency of ACE were significantly higher in pilots （45.06% and 0.67） than that in healthy subjects （31.36% and 0.52）. No difference between the two groups was found for the AGT and ATR1 genotypes. Conclusion： It is suggested that Ⅰ gene of ACE may play a role in performance of the pilots.