保元活血颗粒对老年气虚肾虚证患者免疫功能的影响

Immunoregulation of Baoyuanhuoxue granule in treating aged patients with deficiency of Qi and Kidney

目的:观察老年气虚肾虚证患者的免疫功能状况及保元活血颗粒对其的调节作用。方法:60例老年气虚肾虚患者被随机分为两组,治疗组和对照组各30例,治疗组服用保元活血颗粒治疗,疗程30d,检测T淋巴细胞亚群、自然杀伤细胞(NK细胞)、B淋巴细胞、免疫球蛋白、补体、淋巴细胞非组蛋白图像分析(Ag-Nors)等免疫指标于用药前后的表达情况,与对照组进行比较。结果:老年气虚肾虚证患者的免疫紊乱主要表现为细胞免疫显著下降,固有免疫减低,其中CD3、CD4、CD4/CD8、Ag-Nors、NK细胞水平均有所减低,体液免疫变化不明显。通过保元活血颗粒治疗,能提高老年气虚肾虚证患者的CD3、CD4、CD4/CD8值,提高NK细胞、Ag-Nors水平,对免疫球蛋白、补体、B细胞无明显影响。结论:保元活血颗粒对与老年气虚肾虚证相关的免疫紊乱有调节作用,尤其是细胞免疫,对体液免疫无明显影响。

Objective： To observe the clinic influence and corresponding immunological function changes in treating aged patients with deficiency of Qi and Kidney by Baoyuanhuoxue granule. Methods： 60 aged patients with deficiency of Qi and kidney were randomly divided into two groups. 30 patients in treatment group were treated with Baoyuanhuoxue granule, 30 patients in control group were not any treatment. Observe and analysis the expression of T lymphocyte subsets, NK cell, B-lymphocyte cell, immunoglobulins, C3, CA, Ag-nors before and after treatment in both groups. Results： Baoyuanhuoxue granule could elevate the level of CD3, CD4, CD4/CD8, elevate the level of NK cell and Ag-Nors. There was no significant influence in immunoglobulin, C3, CA and B-lymphocyte cell. Conclusion： Baoyuanhuoxue granule has good therapy function for immunosenescence related to aged patients with deficiency of Qi and Kidney, especially for the cellular immune function.