树突状细胞在大肠腺瘤恶变及早期大肠癌中的意义

Dendritic Ceils and Their Significance in Malignant Transformation of Cojorectal Adenomas and Early Colorectal Carcinomas

用S-100蛋白质抗体对31例正常大肠粘膜、54例大肠腺瘤和7例早期大肠癌标本进行免疫组化染色.结果发现大肠腺瘤和早期大肠癌组织树突状细胞(DC)较正常大肠粘膜明显增多(P<0.01 ).大肠腺瘤组织内DC和淋巴细胞相伴浸润,在绒毛状腺瘤及中、重度不典型增生和局部癌变的腺瘤DC明显增多.提示DC增多和腺瘤恶变有关,DC可能识别腺瘤恶变过程中产生的肿瘤抗原,在局部抗肿瘤免疫中发挥起始作用.动态定量检测腺瘤DC可能有助于早期大肠癌的诊断.

Dendritic cells (DC) were counted on paraffin-embedded tissue section from 31 specimens of normal colorectal mucosa, 54 adenomas and 7 early carcinomas with ABC immunohistochemical method using S-100 protein antibody. The results showed that DC number in adenomas was significantly higher than that in normals and in carcinomas DC number was significantly higher than that in adenomas (P<0.01). DC were often accompanied by lymphocytes in adenomas. In adenomas DC were more frequently seen in villous adenomas and moderate, severe dysplastic lesions. These suggest that the increase of DC is related to malignant transformation of colorectal adenomas. DC could recognize neoantigens expressed by potential malignant cells and DC play an important role in the host local immune reaction against tumor. The dynamic monitoring of DC number in adenomas might be heplful to the diagnosis of early colorectal carcinomas.