CD_（34）阳性成人急性髓系白血病临床及生物学研究

CLINICAL AND BIOLOGICAL STUDY ON CD_34+ ADULT ACUTE MYELOID LEUKEMIA

检测了４０例成人初治急性髓系白血病（ＡＭＬ）细胞ＣＤ＿（３４）抗原的表达，并分析了ＣＤ＿（３４）表达与一般临床特征、其它免疫标志、染色体异常及治疗效果的关系。结果显示，４０例ＡＭＬ中ＣＤ＿（３４）阳性表达１７例，占４２．５％，除Ｍ３无ＣＤ＿（３４）表达外，ＣＤ＿（３４）表达与ＦＡＢ亚型无关。组与组在年龄、性别、初诊时白细胞数、血红蛋白浓度、血小板计数、肝脾肿大及染色体异常均无显著差异。除淋系抗原在组表达明显增高外，其它髓系抗原表达在两组间无差异。组完全缓解率为４１．４８％，明显低于组的７３．９１％。研究提示，ＡＭＬ可能起源于较早期的造血于细胞恶性转化，检测ＣＤ＿（３４）表达对判断ＡＭＬ疗效有一定价值。

CD34 antigen expression in 40 patients(pts)with previously untreated adult acutemyeloid leukemia(AML)was detected,and the clinical and biological characteristics were anal-ysed for AML pts. The results showed that 17 of the 40(42.5%)pts were CD34 positlve.There was no relationship between the CD34 expression and FAB subtypes,and no CD34 expres-sion was observed in M3 subtypes.There was no significant difference in the clinical feattires andchromosome abnormalities between and pts. The lymphoid associatcd antigens wassignificantly increased in AML pts than in pts. The complete remission rate of AML was 41.48%,which is lower than that of AML(73.91%).The study sug-gested that AML may derived from malignant transformation of hemotopoietic stem cell atcarlier stage and the detection of CD34 expression was of some value in predicting trcatment effectin adult AML.