急性白血病患者血浆因子Ⅱ、Ⅴ凝血活性的研究

STUDY ON FACTORⅡAND V COAGULANT ACTIVITY IN PATIENTS WITH ACUTE LEUKEMIA

对４４例急性白血病患者进行了血浆Ⅱ：Ｃ和Ⅴ：Ｃ的研究。正常对照组Ⅱ：Ｃ活性为９９．８３±２９．１９（％），Ⅴ：Ｃ为１０１．５０±３９．７４（％）。疾病活动期、有出血倾向时Ⅱ：Ｃ降低；当外周血幼稚细胞＞６０％时，Ⅱ：Ｃ降低更明显为５９．１９±２４．５５（％）；以上变化有统计学意义（Ｐ＜０．０５）。缓解期，Ⅱ：Ｃ水平有所恢复，但未达正常。Ⅴ：Ｃ仪表现在疾病活动期活性高于正常，为１５２．８４±７７．４８（％）（Ｐ＜０．０１），在其它组变化不明显。研究结果显示Ⅱ：Ｃ与急性白血病出血倾向相关；Ⅴ：Ｃ则可能与白血病细胞促凝活性相关。

Plasma factors Ⅱ and Ⅴ coagulant activity(Ⅱ:C and Ⅴ:C)were studied in44 cases of acute leukemia,The Ⅱ i C and Ⅴ:C was 99.83±29.19(%)and 101.50±39.74(%)respectively in normal controls.The Ⅱ:C decreased markedly in leukemia patients inactive stage and bleeding cases,especially in those whose peripheral blood blast cells>60%(59.19±24.55%).These changes were statistically significant(P<0.05).The Ⅱ:C increasedslightly in patients without bleeding or in remission cases. The Ⅴ:C was increased in activestage(152. 84±77.48%)(P<0;01)and no statistic difference in other groups.We suggestedthat Ⅱ:C might have a referential significance for bleeding cases and Ⅴ:C might correlatewith the active of procoagulant of leukemia cells.