甲状腺乳头状癌中VEGF、bFGF的表达及其与转移的关系

Expression of VEGF ang bFGF in thyroid carcinoma and correlation with metastasis in thyroid carcinoma

目的探讨血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)的表达与甲状腺乳头状癌转移的关系及作用。方法用免疫组织化学S-P法检测伴有和不伴有淋巴结转移的甲状腺乳头状癌中VEGF、bFGF的表达情况。结果在甲状腺乳头状癌组织中VEGF、bFGF表达阳性率分别为63·5%和59·6%,均显著高于正常甲状腺组织(χ2=12·581,P<0·01)、(χ2=12·581,P<0·01);VEGF和bFGF表达阳性率均与甲状腺癌淋巴结转移有关(χ2=4·025,P<0.05)、(χ2=4·712,P<0·05)。结论VEGF、bFGF与甲状腺乳头状癌转移密切相关,VEGF、bFGF表达升高能促进肿瘤转移。

Objective To investigate the expression of vascular endothelial growth factor（VEGF） and basic Fibroblast growth factor（bFGF） and the correlation with metastasis in thyroid carcinoma. Methods Immuohistochemistry S-P technic was used to examinated the expression of VEGF and bFGF in metastatic and nonmetastatic papilly carcinoma. Results The positive expression rate of VEGF and BFGF in thyroid carcinoma was 53.5 % and 59.5% respectively, which was significantly higher than in normal thyroid tissue （X^2= 12.581, P 〈 0.01 ）, （X^2 = 12.581, P 〈 0.01 ） ; The positive rate of expression of VEGF and bFGF was correclated with lymph gland metastasis in thyroidcarcinoma（X^2 = 4.025, P 〈 0.05）, （X^2 = 4.712, P 〈 0.05）. Conclusion Both VEGF and bFGF were closely associated with the metastasis of papilly carcinoma, the high expression of VEGF and bFGF may aggravate tumor metastasis.