MMP-2、PTEN在胃癌中的表达

The Expression of MMP-2, PTEN in gastric carcinoma

目的检测MMP-2、PTEN基因在胃癌组织中的表达,并研究其临床病理意义。方法采用逆转录聚合酶链式反应(RT-PCR)法检测MMP-2、PTEN在40例胃癌中的表达。结果①PTNM分期Ⅰ、Ⅱ期胃癌与对照组正常胃黏膜组织MMP-2、PTEN的表达均有显著性差异(P<0·01);PTNM分期Ⅲ、Ⅳ期和Ⅰ、Ⅱ期胃癌MMP-2、PTEN的表达均有非常显著性差异(P<0·05);②MMP-2、PTEN在高、中分化腺癌和低分化胃癌阳性率表达差异均具有显著性(P<0·05)。③MMP-2、PTEN在有淋巴结转移组和无淋巴结转移组检出阳性率差异具有显著性(P<0·05)。结论MMP-2、PTEN的表达与胃癌临床病理特征和生物学行为存在密切关系,MMP-2、PTEN基因是胃癌细胞增生活跃的重要影响因素。

Objective To explore the expression of tumor-related genes MMP-2 and PTEN and their clinic pathological significances in gastric carcinoma tissues. Methods The expression of MMP-2, PTEN from 40 patients with gastric carcinoma were investigated by RT-PCR. Results （1）There existed significant differences between normal control and PTNM stage Ⅰ、Ⅱ （P 〈 0.01） ; as well as the stages Ⅰ、Ⅱ with stages Ⅲ、 Ⅳ for the expression of MMP-2, PTEN（P 〈 0.05）. （2）There existed significant differences between the expression rates of MMP-2 and PTEN in the high or middle differentiation grade of the carcinoma detected and the low grade＇ （P 〉 0.05）. （3）There existed significant differences between the expression rates of MMP-2 and PTEN in the patients with lymph metastasis and those without lymph metastasis（ P 〈 0.05）. Conclusion The expressions of MMP-2 and PTEN has close relationship with the pathology of gastric carcinoma and their own biology behaviors. Both MMP-2 and PTEN play important roles in the distinct hyperplasia of gastric carcinoma.