组织工程生物反应器的力学环境特点

Characteristics of mechanics environment of bioreactor in tissue engineering

组织工程学是一门以细胞生物学和工程学为基础,应用工程学和生命科学的原理,开发器官缺损患者所需代替物,并构建和保持或增强其组织功能性的一门交叉学科。生物反应器作为组织工程中非常重要的工具,目前主要是从生物力学问题、三维空间培养问题、传质问题、培养的环境条件问题(pH、氧张力等)和物理因素(电场、磁场、应力场)等方面开展其研究。本文作者主要从生物力学角度介绍组织工程生物反应器研究的最新进展,重点探讨组织工程生物反应器的力学环境。

Tissue engineering is a kind of interdisciplinary study based on applying the principles of both engineering and life sciences for the development of biological substitutes and try to restore, maintain or improve the tissue function. Bioreactors are used in tissue engineering study as very important devices. Currently, the research on the improvement of bioreactors are mainly stressed on the biomechanics, three-dimensional culture, mass transport, the culture environment condition （pH, the oxygen tension, etc.） and physics factors such as electric filed, magnetic field, stress field,etc. The discussion about bioreactors in this paper mainly probe into the biomechanics problems of Bioreactors in tissue engineering.