血浆NO含量测定在预测一氧化碳中毒患者发生迟发性脑病中的临床意义

Clinical significance of detecting plasma nitric oxide in delayed brain disease following acute carbon monoxide poisoning

目的探讨测定血浆一氧化氧(NO)含量对预测急性一氧化碳中毒(CO)患者与发生迟发性脑病的意义。方法将62例急性CO中毒患者分为两组,迟发性脑病组(A组)29例和未发生迟发性脑病组(B组)33例。采用检测NO的中间代谢产物亚硝酸盐来反映A、B两组患者连续血浆的NO水平,并与正常对照组进行比较。结果A、B两组中毒后第1天血浆NO含量均明显低于正常对照组(P<0.01),A、B两组第5天血浆NO含量均明显低于正常对照组(P<0.05),A组第10天血浆NO含量明显低于B组、正常对照组(P<0.05)。结论动态观察急性CO中毒后病人血浆NO变化有助于预测迟发性脑病的发生。

Objective To explore the chinical significance of variation of plasma nitric oxide （PNO） level in predicting the occurrence of delayed brain disease following acute carbon monoxide poisoning（COP）. Methods Nitites of NO middle substance were detected, standing for the PNO level, in the patient and contral groups. Results The PNO level of patients with acute COP was obviously lower than that of control group. The PNO level of patients with delayed hrain disease following acute COP was lower than that of the group without delayed brain disease and control group on the fifth day and tenth day. Conclusion It is helpful to predicting the oc- currence of delayed brain disease following acute COP by measuring constantly the PNO level of patients.