HBV感染者血清e抗原与HBV-DNA的相关性分析

The correlative analysis beween serum levels of HBeAg And HBV-DNA in persons infected hepatitis B virus

目的分析乙型肝炎病毒DNA(HBV-DNA)和乙型肝炎病毒e抗原(HBeAg)的相关性。方法收集乙型肝炎患者695例,时间分辨免疫荧光测定患者血清乙型肝炎e抗原(HBeAg),同时荧光定量PCR测定患者血清HBV-DNA。根据血清HBeAg和HBV-DNA水平各分9组。结果1)HBV感染者血清e抗原与HBV-DNA呈等级相关,(0.508,P<0.001)。2)血清HBeAg各组与HBV-DNA的相关性随着HBeAg浓度的增大而减弱(F=32.79,I～IV组P<0.05)。3)血清HBV-DNA各组间HBeAg没有统计学意义差别(F=0.369,P>0.05)。结论乙型肝炎患者血清HBeAg和HBV-DNA近低度相关。

Objective To analyse the correlation of HBV-DNA and HBeAg in infected persons. Methods Serum HBeAg and HBV-DNA in 695 infected persons were detected by time resolved fluorescence immunoassay and fluorescence quantitative PCR. 9 groups were divided acording to their serum levels. Results 1）The levels of HBeAg and HBV-DNA showed rank correlation（0.508, P〈0.001）. 2）The correlation among the different groups of HBeAg and the HBV-DNA was decreased with the increasing concentration of HBeAg（ F=32.79, P〈0.05 in the Ⅰ～Ⅳ groups）. 3） It showed no statistically different among groups of HBeAg and HBV-DNA （ F=0.369, P〉0.05）. Conclusion The serum levels of HBeAg and HBV-DNAs in persons infected hepatitis B reveal a lower correlation.