狂犬病疫苗不同免疫方法的实验研究

AN EXPERIMENTAL STUDY ON THE DIFFERENT IMMUNE METHODS OF RABIES VACCINE.

选择１５３名中学生，随机分为８组，以不同免疫程序、途径、剂量和部位进行免疫接种。结果表明：免疫程序主要影响免疫后抗体出现的早晚，免疫途径和剂量可影响免疫后抗体反应的幅度，接种臀部与肱三头肌处肌注的抗体反应无差异（Ｐ＞０．０５）。不同性别、年龄的免疫反应无明显差异。本次实验提示我们：用国产地鼠肾细胞疫苗（ＰＨＫＣＶ）常规接种及其他初免程序难以保护潜伏期较短的狂犬病者，故对狂犬病高危人群、重点人群应预先免疫；又因国产ＰＨＫＣＶ免疫持久性较差，因此对于再次被咬伤者仍应接种疫苗。

53 students selected were divided into eight groups randomly and were inoculated by immune schedules,immune channels,doses and inoculated sites in difference. The results indicated that the different immune schedules effect mainly apperance of antibody reactions in early or late, the different immune channels and doses can effect antibody reactions in extent. Whether or not the distinct inoculative sites relate to antibody reactions,the antibody reactions of injection in the buttock and musculus triceps brachii are not obvious difference. Whether or not antibody reactions vary from sex and age,the difference can not be found in the study.The results indicated that the cases of short incubation period of rabies could not be protected by schedule of conventional 5 doses and other schedules with PHKCV made in our country, so the population in high risk of rabies or major population should immunize in advance. Because immune lasting of PHKCV made in our country is disappionting the cases of second time bited should be inoculated with PHKCV again.