自发性高血压大鼠下丘脑和血浆ET、CGRP含量变化的研究

Content change of ET,CGRP in hypothalamus and plasma of spontaneously hypertensive rats.

本实验动态测定自发性高血压大鼠（ＳＨＲ）不同时期下丘脑和血浆ＥＴ、ＣＧＲＰ含量的变化以及其局部脑缺血后不同时期的改变。结果发现，ＳＨＲ３月龄和７月龄其下丘脑和血浆中的ＥＴ含量均明显高于同龄Ｗｉｓｔａｒ鼠（ＷＲ）（Ｐ＜０．０１），而ＣＧＲＰ含量均明显低于同龄ＷＲ（Ｐ＜０．０１）。局部脑缺血后２４小时，无论ＳＨＲ还是ＷＲ，其下丘脑和血浆ＥＴ和ＣＧＲＰ均比缺血前明显增高（均Ｐ＜０．０１）。缺血持续７天时，除ＳＨＲ下丘脑和血浆ＥＴ水平仍保持高水平外，其余均恢复正常。结果提示。

In this study, ET and CGRP levels in hypothalamus and plasma of SHR and which with focal cerebral ischemia were dynamic measured. The results showed that ET contents in hypothalamus and plasma of 3 months SHR and 7 months SHR were higher remarkably than that of Wistar rats(WR) with same age( P <0.01).The CGRP contents in hypothalamus and plasma of both age SHR were less than that of WR with same age( P <0.01).When focal cerebral ischemia for 24 hours in SHR and WR, both ET and CGRP contents in hypothalamus and plasma were increased remarkably than that of unischemic SHR and WR( P <0.01). When focal cerebral ischemia for 7 days, CGRP levels of SHR and WR were all recovered to the levels of unischemia,but the ET contents in both hypothalamus and plasma of SHR were still keep higher levels than that of unischemic SHR. The results suggested that high level ET contents and lower level CGRP contents of SHR may be play an important role in the forming, and development of hypertension.