急性脑血管病患者红细胞膜流动性与血脂关系的探讨

Relationship between erythrocyte membrane fluidity and serum lipids in patients with acute cerebravascular disease.

采用荧光偏振度方法，对７０例急性脑血管病（ＡＣＶＤ）患者（脑出血３３例、脑血栓形成３７例）和３０例健康人的红细胞膜流动性作了检测，并同时测定血清脂质、脂蛋白及载脂蛋白Ａ１、Ｂ的含量。结果：ＡＣＶＤ患者的红细胞膜荧光偏振度和微粘度均高于健康人（Ｐ＜０．０１），脑出血组与脑血栓形成组无差异（Ｐ＞０．０５）。ＡＣＶＤ患者的总胆固醇、甘油三脂、载脂蛋白－Ｂ明显升高，高密度脂蛋白、载脂蛋白－Ａ１明显降低（Ｐ＜０．０５～０．０１）。

We measured the erythrocyte membrane fluidity by fluorescence polarimatry to 70 patients with ACVD(33 hemorrhagic and 37 thrombotic strokes) and 30 healthy controls.We also measured the serum lipid, lipoprotein cholesterol and apolipoproteins A 1,B from these patients and controls. The results showed as follow:(1)The fluorescence polarization and the microviscosity of patients with ACVD were significantly higher than normal group( P <0.01); (2)No significant difference were revealed between the group of hemorrhagic and the group of thrombotic strokes( P >0.05). (3)The cholesterol and the triglyceride lipoproteins and apolipoproteins B were found significantly higher and high density lipoprotein cholesterol and apolipoproteins A 1 were significantly lower( P <0.05～0.01) in patients with ACVD than in normal control group. The study preliminary discussed the relationship between erythrocyte membrance fluidity and serum lipids in patients with ACVD.