重庆医科大学儿童医院急性呼吸道感染住院患儿病毒病原学分析

Analysis of virus pathogens in children hospitalized with acute respiratory infection in Chongqing Children's Hospital

目的分析住院急性呼吸道感染(ARI)患儿病毒病原检测结果,为临床儿童急性呼吸道感染提供病毒病原学诊断依据。方法选择2003年4月至2005年3月重庆医科大学儿童医院呼吸内科住院治疗的急性呼吸道感染患儿,取其鼻咽分泌物做免疫荧光检测筛查7种常见呼吸道病毒抗原,包括呼吸道合胞病毒(RSV)、腺病毒、流感病毒A及B型、副流感病毒Ⅰ、Ⅱ、Ⅲ型,对检测标本阳性的病例进行统计分析。结果1052份标本中,阳性标本409份,占38.88%。其中RSV阳性标本360份,占总阳性标本例数的88.02%,副流感病毒Ⅲ37份占9.05%;RSV发病高峰时期在12月至次年2月和7、8月两个时期;RSV感染多见于3岁以下,发病高峰年龄为2～6个月,男女发病比例为2.24∶1。结论2003～2005年重庆地区急性呼吸道感染的病毒病原体仍以RSV为主。

Objective To analyse the virus pathogens that caused children hospitalized with acute respiratory infection in Chongqing from 2003 to 2005. Methods The 7 common respiratory viruses,including respiratory syncitial virus （ RSV ） , adenovirus, influnenza A and B, and parainfluenza 1,2,3, were detected by using immunofluenscence viral antigen rapid diagnosis in nasopharyngeal aspirate （ NPS） of children with acute respiratory infection. Results In totally 1052 samples,38.88% （ 409/1052） was shown to be viral positive. 360 samples were RSV positive and 37 samples were parainfluenza 3 positive. The peak season of RSV infection was between December and February. Another epidemiological season might in July and August. Most of RSV infection cases were less than 3 years old. The ratio of male to female was 2：1. Conclusion RSV is the most common viral pathogen in children hospitalized with acute respiratory infection in Chongqing from 2003 to 2005.