天津市儿童医院住院腹泻患儿星状病毒感染检测分析

Analysis and determination of astrovirus infection in children hospitalized with diarrhea in Tianjin Children's Hospital

目的了解天津地区腹泻患儿星状病毒感染的临床与流行病学特点。方法以酶联免疫吸附法检测腹泻患儿粪便中星状病毒抗原以及轮状病毒抗原。结果2003年天津市儿童医院344例住院腹泻患儿中,星状病毒抗原检出率16.6%(57/344),同时合并轮状病毒感染者9.9%(34/344),发病年龄集中于1个月至2岁,感染多发生于冬季,临床症状与轮状病毒感染相似,预后良好。结论星状病毒感染可能是天津等中国北方地区儿童腹泻的重要病因之一,开展病原学检测有助于避免滥用抗生素及预防暴发流行。

Objective To study clinical and epidemiological features of astrovirus infection in baby patients suffering from diarrhea in Tianjin. Methods To examine the astrovirus antigen and the rotavirus antigen in the stool of baby patients with diarrhea via EIA. Results Of the 344 baby patients with diarrhea, the astrovirus antigen rate was 16.6% （ 57/344）, and the simultaneous rotavirus infected person rate reached 9.9% （ 34/344） ; the invasion age ranged from one month old to two years old; the infection usually occurred in winter; it was difficult to tell the clinical symptoms of astrovirus from that of rotavirus infection ; and the prognosis was excellent. Conclusion Astrovirus infection may be one of the main causes of the diarrhea in baby patients in Tianjin and other northern regions, and launching etiology examination helps to avoid abusing antibiotic and prevent epidemic disease from breaking out.