2Ohtsu A,Baba H,Sakata Y,et al.Phase Ⅱ study of S-1,a novel oral fluoropyrimidine derivative in patients with metastatic colorectal cancer[J].BrJ Cancer,2000,83:141-145.
3Miwa M,Ura M,Nishida M,et al.Design of a novel oral fluoropyrimidine carbamate,capecitabine,which generates 5-fluorouracil selectively in tumours by enzymesconcentrated in human liver and cancer tissue[J].Eur J Cancer,1998,34(8):1274-1281.
4Miyadera K,Sumizawa T,Haraguchi M,et al.Role ofthymidine phosphorylase activity in the angiogenic effect of platelet derived endothelial cell growth factor/thymidine phosphorylase[J].Cancer Res,1995,55(8):1687-1690.
5Hoff P M,Ansari R,Batist G,et al.Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer.Results of a randomized phase Ⅲ study[J].J Clin Oncol,2001,19:2282-2292.
7Be'couam Y,Ychou M,Ducreux M,et al.Phase Ⅱ trail of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients[J].J Clin Oncol,1998,16:2739-2744.
8Bleiberg H.Oxaliplaitin(L-OHP):a new reality in colorectal cancer[J].Br J Cancer,1998,77:1-3.
9Cunningham D,Pyrhonen S,James R D,et al.Randomized trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer[J].Lancet,1998,352:1413-1418.
10Rougier P,Cutsem E V,Bajetta E,et al.Randomized trail of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectalcancer[J].Lancet,1998,352:1407-1412.
6Sinicrope FA, Hart J. Relationship of P-glycoprotein and carcinombryonic antigen expression in human colon carcinoma to local invasion [J]. Cancer, 1991, 74: 2908.
7Honkoop AH. Diest P J, Jong JS, et al. Prognostic role of clinic, Pathologgical and biological, Characteristics in patients with locally advanced breast cancer[J]. Br J Cancer, 1998, 77:621.
8Pirker R, Wallner J. MDR1 gene expression in primary colorectal carcinoma [J]. Br J Cancer, 1993, 68: 691.
9Dong M, Bernaud J, Espinosa L, et al. In vitro and in vivo reversal of cancer cell muhidrug resistance by the semisynthetic antibiotic tiamulin [J]. Biochem Pharmacol,1998, 56 (9): 1219-1228.
10Dolfini E, Dasdia T, Arancia G, et al. Characterization of a clonal human colon adenocarcinoma line intrinsically resistant to doxorubicin [J]. Br J Cancer, 1997, 76 (1): 67-76.
