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脑局部亚低温治疗急性脑梗死临床观察

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摘要 目的探讨脑局部亚低温治疗急性脑梗死的疗效,及最佳治疗时间窗。方法将收治的120例急性脑梗死患者随机分成治疗组60例和对照组60例,对照组予常规的抗凝护脑等药物治疗,治疗组在常规药物治疗基础上加用脑局部亚低温治疗,分别评定治疗前后的神经功能缺损评分(NDS)并测定治疗前后患者血清肿瘤坏死因子α(TNF-α),其中治疗组又按开始治疗时间分成3组:A组:发病6小时内;B组:发病6-24小时;C组:发病24小时后。结果治疗组神经功能缺损评分及TNF-α下降均较对照组明显,其中尤以A组更为明显。结论脑局部亚低温治疗急性脑梗死有效,治疗最佳时间窗在6小时,其机制可能与抑制炎性细胞因子等有关。
作者 钟洁静 孙新芳 吴承龙 王黎萍
机构地区 绍兴市人民医院
出处 《心脑血管病防治》 2005年第6期39-40,共2页 CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
关键词 脑局部亚低温 脑梗死 时间窗 肿瘤坏死因子
分类号 R743.33 [医药卫生—神经病学与精神病学]
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参考文献5

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二级参考文献14

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心脑血管病防治
2005年 第6期

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