糖化血清蛋白与血糖控制效果的实验研究

Experimental study on glycosylated serum protein and glycose surveillance

目的探讨糖化血清蛋白(GSP)与糖尿病控制效果及并发症的关系。方法临床确诊的糖尿 病患者300例作为病例组,以健康体检者100例作为对照组,测定两组的血糖和血清GSP。结果病例 组GSP正常者与GSP异常者之间平均血糖水平、血糖异常率及糖尿病并发症发生率皆有显著性差 异(P<0．01),GSP异常者血糖大于6．1 mmol,／L者达到70．1％,说明血糖控制效果较差,并发症发生率 为78．4％,明显高于GSP正常者。结论GSP是反映糖尿病近期内控制情况及预测并发症的良好指标。。

Objective To investigate the significance of glycosylated serum protein（GSP） in detecting the state and complications of diabetes. Methods Serum GSP and glycose levels in 300 patients with diabetes and 100 healthy people were measured. Results There was significant difference in average serum glycose levels, the rate of abnormal glycose and the incidence of diabetes complications between GSP normal group and abnormal group of diabetes（P 〈 0.01）. In GSP abnormal group, serum glycose levels of 70.1% patients exceeded 6.1 mmol/L, indicating the bad control states of diabetes, and the incidence of complications was 78.4%, which was much higher than that of GSP normal group. Conclusion GSP can be used as a good surveillance index in evaluating control states and prognosticating complications of diabetes.