三种超促排卵方案的临床应用效果分析

A retrospective analyze of three kinds of tropichyperovulation programme: ovarian response and clinical outcomes

目的比较三种控制性超促排卵(COH)方案在体外受精胚胎移植(IVFET)/卵胞浆内单精子注射(ICSI)的临床结果,分析人尿绝经期促性腺激素(HMG)和基因重组促性腺激素(rFSH)的应用价值。方法回顾性分析570例接受IVFET/ICSI的不育患者,采用三种COH方案的情况。A组50个周期,应用HMG;B组81个周期,应用rFSH;C组445个周期,rFSH结合HMG促排卵。结果B组用药天数少于A组(P<0.05),用药安瓿数少于A组和C组,有统计学差异(P<0.05);B组获卵数明显多于A组和C组(P<0.01,P<0.05)。结论COH中应用rFSH可以募集较多的卵泡,三种COH方案的胚胎发育情况、临床妊娠率、胚胎移植结局无显著差异。

Objective To compare the clinical outcome of three kinds of controlled ovarian hyper stmulation programe in women umdergoing in-vitro fertilization （IVF-ET） / intracytoplasmic sperm injection （ICSI） . Methods Clinical data of 570 infertile women（576 cycles） after IVF-ET / ICSI were analyzed retrospectively Following down regulation in a long gonadotro- phin-releasing hormone（GnRH） agonist protocal , patients received three different tropichyperovulation programme according ecanomic situation and ovarian response. Group A 50 cycles , only with HMG ; Group B 81 cycles , only with Gonal-F ; Group C 445 cycles , mixed Gonal-F with HMG. Results The duration of Gn treatment was significantly shorter in group B than group A （P〈0. 05） . The numbers of anpoules in groups B was significantly less than group A and group C （P〈0. 05） . And there were significantly more follicles and more oocytes retrieved in group B than in group A and group C （P〈0.01, P〈0. 05）. Conclusion Although there were significantly more follicles and more oocytes retrieved in group B. There was no significant difference in the rates of implantation and pregnancy among three groups.