血清巨噬细胞集落刺激因子的检测在子宫内膜癌的临床意义

The significance of detection of serous M-CSF in endometrial carcinoma

目的探讨巨噬细胞集落刺激因子(MCSF)与子宫内膜癌的关系。方法采用放免法测子宫内膜癌和子宫肌瘤各40例及健康妇女30例空腹血清MCSF,并于术后20天、术后40天,同期测CA125作对照。结果子宫内膜癌组血清MCSF均值高于肌瘤组及对照组(P<0.05);内膜癌MCSFⅡ期以上均值高于Ⅰ期(P<0.05);术前与术后相比,MCSF显著下降(P<0.05);内膜癌MCSF阳性率Ⅰ期为27.3%,CA12518.2%,联合阳性率为63.6%;II期以上MCSF阳性率44.4%,CA12538.9%,联合阳性率72.2%。结论子宫内膜癌手术分期越高血清中的MCSF水平越高,可能与肿瘤消长有关,对于监测病情、预测预后有一定的参考价值;MCSF与CA125联合检测,可以提高早期子宫内膜癌的阳性检出率。

Objective To study the relationship between Macrophage colony-stimulating-factor and endometrial carcinoma. Methods Serous M-CSF levels were measured by radio immunological assay in 40 cases of primary endometrial carcinoma, and benign uterine lesions and 30 cases healthy women respectively. Besides serous M-CSF and CA125 level~ were measured on post-operation the 20th and 40th day in endometrial carcinoma patients and CA125 were measured to be control. Results The serous M-CSF in groups of endometrial carcinomas is significantly higher than that in benign uterine lesions and normal control groups, P〈0. 05;mean of serous M-CSF in endometrial carcinomas over operative-stage Ⅱ is significantly higher than in groups of operative-stage Ⅰ, Compared with post-operation, pre-operative mean of M-CSF is higher than the post-operative, P〈0. 05; M-CSF-positive rate in endometrial carcinoma stage Ⅰ is 27. 3% ,CA125 is 18. 2% , combination is 63.6%;over stage Ⅱ , M- CSF is 44.4% ,CA125 38.9% ,combination is 72. 2%. Conclusion The higher the operative- stage of a, the higher the serous M- CSF levels are ,it is probably related with the development of the carcinoma, which may be of value in monitoring the illness and predicting the prognosis ; Detection of M-CSF combined with CA125 can elevate the early diagnosis rate of endometrial carcinoma.