臀肌挛缩症患者T淋巴细胞及其亚群的研究

Study on T-lymphocytes and its subsets in patients with gluteal muscle contracture.

目的研究臀肌挛缩症的免疫发病机理。方法用流式细胞仪检测43例儿童臀肌挛缩症患者和22例正常体检儿童的外周血T淋巴细胞及其亚群。结果儿童臀肌挛缩症患者的CD4+水平、CD4+/CD8+比值较正常儿童升高(P<0.05),而总T细胞和CD8+水平则两组间差异无显著性(P>0.05)。结论儿童臀肌挛缩症患者存在免疫调节紊乱,认为免疫因素可能是其重要发病机理之一。

Objective To study the immunological pathogenesis of gluteal muscle contracture. Methods In 43 children of gluteal muscle contracture and 22 normal controls, peripheral blood T - lymphocytes and its subsets were analysed with flow cytometry. Results The percent of CD4^＋ and ratio of CD4^ ＋/CD8^ ＋ in children with gluteal muscle contracture were significantly higher than that in normal controls （P 〈 0.05）. There were no significant differences in the percent of total T - lymphocytes and CD8^ ＋ between the two groups （ P 〉 0.05）. Conclusion There is disorder of immunological regulation in children with gluteal muscle contracture. Immunologic factor may play an important role in the gluteal muscle contracture.